Weight Loss Clinic in Stoneygate

GLP-1 weight loss treatment for Stoneygate residents

Stoneygate residents typically come to GLP-1 treatment with prior knowledge of the medication — the Mounjaro and Wegovy stories have been mainstream news since 2023. The questions are usually specific: Which is better for my specific situation? What about long-term safety? How does this compare to NHS Tier 3? What happens if I stop?

Clarendon Pharmacy is a mile and a half from Stoneygate — seven minutes by car via London Road onto Welford Road. Mohammed Kolia (MPharm, IP) is a GPhC-registered Independent Prescriber. Assessment, prescription, dispensing and monthly reviews all happen in one place.

How do Mounjaro and Wegovy work?

Both mimic GLP-1, a hormone naturally released after eating that signals fullness and slows stomach emptying. Mounjaro additionally acts on GIP, making it a dual GLP-1/GIP agonist. You feel full sooner on smaller meals, hungry less often between meals, food cravings reduce, satiety prolongs.

Which is right for me — Mounjaro or Wegovy?

In direct head-to-head trials, Mounjaro tends to produce greater average weight loss than Wegovy:

• Mounjaro at full dose (15mg weekly) — SURMOUNT-1 trial: 21% body-weight reduction over 72 weeks.
• Wegovy at full dose (2.4mg weekly) — STEP-1 trial: 15% body-weight reduction over 68 weeks.

But individual response varies hugely. Some patients respond better to Wegovy than Mounjaro, or tolerate Wegovy better. Tolerability differs — the side-effect profiles overlap but aren't identical. Independent prescribing means we can switch you between products if one isn't working. Other factors that influence choice: cost (Mounjaro slightly more expensive at most doses), dose escalation schedule (both have 4-month ramps), and storage (both shelf-stable for 30 days at room temp once started).

NICE eligibility

For South Asian, Black African and Black Caribbean populations, NICE recommends adjusted lower thresholds (27.5 instead of 30) due to earlier-onset cardiovascular risk.

Long-term safety: what we know and what we don't

Mounjaro and Wegovy have been licensed for weight management since 2021–2023, but the underlying GLP-1 mechanism has been used for type 2 diabetes since 2005 (Byetta/exenatide). The diabetes data shows good long-term safety up to 15+ years of continuous use. The newer weight-management indications use higher doses, but the safety signals have remained consistent: gastrointestinal side effects (mostly transient), rare pancreatitis, rare gallbladder problems, contraindicated in medullary thyroid cancer history. No long-term cancer signal in human populations to date.

The honest unknowns: very long-term effects of staying on GLP-1 treatment for decades aren't fully characterised yet. Most clinical guidance assumes 1–2 years of treatment then taper, with lifestyle changes embedded during that window.

What to expect month-by-month

Weeks 1–4: modest appetite reduction, possible mild nausea, 1–3kg loss. Weeks 5–8: appetite suppression more pronounced, side effects settling. Months 3–6: dose escalates to maintenance, 5–12% body weight loss typical. Months 6–12: 15–20% total weight loss common; metabolic markers improve substantially.

Side effects: the full picture

Most common (>10%): nausea, indigestion, constipation or diarrhoea, weeks 1–8. Less common: gallbladder problems; pancreatitis (rare); thyroid effects (contraindicated in medullary thyroid cancer history or MEN-2); injection site reactions. Full data at the eMC SmPC for Mounjaro KwikPen.

The stopping question

Weight regain is the honest concern with GLP-1 treatment — trials show ~two-thirds of lost weight returns within a year of stopping, unless lasting behavioural changes are embedded. The strategy that works: use GLP-1 treatment as a window to embed habits that survive without it (strength training, protein-forward eating, structured eating windows, resolved sleep debt). Then taper rather than stopping abruptly, ideally with continuing review.

How much does treatment cost?

Pricing varies by dose. We charge for medication only — initial consultation, monthly reviews, injection demonstration, and prescription are all included. No subscription, no auto-billing, no contract. Full monthly figure given at consultation.

Getting to Welford Road from Stoneygate

1.5 miles south via London Road onto Welford Road — about seven minutes by car. Free patient parking on-site. The 47, 84, 85 and 88 buses connect Stoneygate to Welford Road. For walkers, about 25–30 minutes via Knighton Park.